Bedside stratification of patients according to CYP2C19*2 genotype

Rasa Karaliūtė, Olivija Gustienė, Nora Kupstytė, Daiva Ambrasienė, Vacis Tatarūnas

Abstract


Objective. The task was to identify the defective CYP2C19*2 allele by using a novel fast-genotyping method in the patients having coronary artery disease who developed stent thrombosis or high on-treatment platelet reactivity.
Materials and methods. A total of 35 patients were included in the study. All the patients were screened for CYP2C19*2 using Spartan RX CYP2C19 Assay Package.
Results. CYP2C19*1*1 variant was found in 63%, *1*2 in 34%, *2*2 in 3% of patients. The distribution of genotypes was similar in men and women.
Conclusions. By using the bedside technique, CYP2C19*2, which is responsible for a poorer effect of clopidogrel, might be identified in less than an hour.

Keywords


stent thrombosis; CYP2C19; clopidogrel; gender; antiplatelets; genotype

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DOI: https://doi.org/10.6001/biologija.v64i2.3740

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ISSN 1392-0146 (Print)
ISSN 2029-0578 (Online)