Recent advances in biomolecular analysis by ultraviolet surface-enhanced resonance Raman spectroscopy: A review

Martynas Talaikis; Lina Mikoliūnaitė; Valdas Šablinskas; Sonata Adomavičiūtė-Grabusovė; Gytautė Sirgėdaitė; Evaldas Stankevičius; Gediminas Niaura

doi:10.6001/chemija.2025.36.3.4

Martynas Talaikis
Lina Mikoliūnaitė
Valdas Šablinskas
Sonata Adomavičiūtė-Grabusovė
Gytautė Sirgėdaitė
Evaldas Stankevičius
Gediminas Niaura

DOI: https://doi.org/10.6001/chemija.2025.36.3.4

Keywords: UV-SERS, resonance, Raman, plasmonic, adenine

Abstract

Ultraviolet surface-enhanced resonance Raman spectroscopy (UV-SERRS) offers the ultrasensitive, reliable and selective analysis and sensing of biomolecules due to the combination of surface-enhancement and resonance enhancement of the Raman signal of studied molecules. In this Review, we provide the background of the technique and discuss the challenges related to ultraviolet plasmonics as well as the ability to employ the non-plasmonic substrates. We also highlight the recent applications of UV-SERRS in analysis of biomolecules. Finally, the advantages and future directions of the method are provided.